Synthetic Organic Chemistry
prof dr. F.P.J.T. Rutjes and dr. F.L. van Delft
contact F.vanDelft@science.ru.nl
The main expertise of the group Synthetic Organic Chemistry comprises the chemical construction of several types of natural or unnatural (designed) carbohydrates. Several classes of carbohydrate-containing compounds can be synthesized in our lab, such as oligosaccharides, glycopeptides, oligonucleotides, aminoglycoside antibiotics or aminosugars. Usually, we design and prepare analogues of natural products driven by a science-based question, for example to study a particular biochemical system, to visualize a biological process, or to change unfavorable characteristics associated with the natural counterpart. Specific examples of compounds prepared include:
- metabolically stable isosteres of glycopeptides
- deoxygenated analogues of aminosugars
- fluorescently labeled sugars, e.g. nucleotides and aminoglycoside antibiotics
- novel RNA-targeting ligands based on 2-deoxystreptamine
If required novel chemistry will be developed to fullfill a specific desire. One has to be aware that theoretically any oligosaccharide (2-5 sugars) can be prepared on a (semi)preparative scale, but the time-investment for complex structures is usually large, particularly in comparison with peptide- and oligonucleotide synthesis. For further information concerning more details of our work, please visit our website at http://www.molchem.science.ru.nl/rutjes